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    • Involvement of A13 dopaminergic neurons in prehensile movements but not reward in the rat 

      Garau, Celia; Hayes, Jessica; Chiacchierini, Giulia; Mccutcheon, James Edgar; Apergis-Schoute, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-09)
      Tyrosine hydroxylase (TH)-containing neurons of the dopamine (DA) cell group A13 are well positioned to impact known DA-related functions as their descending projections innervate target regions that regulate vigilance, sensory integration, and motor execution. Despite this connectivity, little is known regarding the functionality of A13-DA circuits. Using TH-specific loss-of-function methodology ...

    • Predictive and motivational factors influencing anticipatory contrast: A comparison of contextual and gustatory predictors in food restricted and free-fed rats 

      Hayes, Jessica; Garau, Celia; Chiacchierini, Giulia; Urcelay, Gonzalo P.; McCutcheon, James Edgar; Apergis-Schoute, John (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-23)
      In anticipation of palatable food, rats can learn to restrict consumption of a less rewarding food type resulting in an increased consumption of the preferred food when it is made available. This construct is known as anticipatory negative contrast (ANC) and can help elucidate the processes that underlie binge-like behavior as well as self-control in rodent motivation models. In the current investigation ...

    • Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity 

      Chiacchierini, Giulia; Naneix, Fabien; Peters, Kate Z; Aspergis-Schoute, John; Snoeren, Eelke; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Control of protein intake is essential for numerous biological processes as several amino acids cannot be synthesized de novo, however, its neurobiological substrates are still poorly understood. In the present study, we combined in vivo fiber photometry with nutrient-conditioned flavor in a rat model of protein appetite to record neuronal activity in the VTA, a central brain region for the control ...

    • Restriction of dietary protein in rats increases progressive-ratio motivation for protein 

      Chiacchierini, Giulia; Naneix, Fabien; Apergis-Schoute, John; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-29)
      Low-protein diets can impact food intake and appetite, but it is not known if motivation for food is changed. In the present study, we used an operant behavioral task – the progressive ratio test – to assess whether motivation for different foods was affected when rats were maintained on a protein-restricted diet (REST, 5% protein diet) compared to non-restricted control rats (CON, 18% protein). ...